Is Mycoplasma genitalium a common STI?

Yes, Mycoplasma genitalium is estimated to affect 1–2% of the general population. It is now recognised by the British Association for Sexual Health and HIV (BASHH) as a significant STI requiring specific testing.

Why isn't Mycoplasma included in standard STI tests?

Mycoplasma genitalium requires a specific nucleic acid amplification test (NAAT) that is not included in routine STI screens. If you have persistent symptoms after treatment for chlamydia or gonorrhoea, Mycoplasma testing is recommended.

Can Mycoplasma genitalium be cured?

Yes, with the correct antibiotics. However, resistance to first-line antibiotics (azithromycin) is common. Resistance-guided therapy, where the bacterium is tested for antibiotic sensitivity, gives the best cure rates.

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Mycoplasma Genitalium

Medically ReviewedOften Asymptomatic

Mycoplasma genitalium is a bacterial STI increasingly recognised as a cause of urethritis and cervicitis. It requires specific testing (not included in standard STI screens) and targeted antibiotic treatment. Resistance-guided therapy is now recommended to ensure effective treatment.

Mycoplasma Genitalium: Key Facts

Often Asymptomatic

Incubation Period: 1–5 weeks
Test Window: 2 weeks post-exposure
Results: 3–5 working days
Treatment: Targeted antibiotics (resistance-guided therapy)
Cure Rate: 90–95% with resistance-guided treatment

Book Mycoplasma Test – £156

Results within 24 hours • Same-day treatment available

Symptoms of Mycoplasma Genitalium

Common Symptoms

Often no symptoms (many infections are asymptomatic)
Urethritis symptoms
Discomfort when urinating

Symptoms in Men

Discharge from the penis
Burning or stinging when urinating
Urethral irritation

Symptoms in Women

Unusual vaginal discharge
Pain during sex
Bleeding after sex or between periods
Lower abdominal pain

How is Mycoplasma Genitalium Transmitted?

Vaginal sex
Anal sex
Possibly oral sex (less common)
Genital-to-genital contact

Prevention

Use condoms consistently
Specific testing if symptoms persist after chlamydia/gonorrhoea treatment
Partner notification and treatment
Limit number of sexual partners

Complications if Untreated

Pelvic inflammatory disease (PID) in women
Infertility
Epididymitis in men
Increased risk of preterm birth
Antibiotic resistance

Frequently Asked Questions

Medically Reviewed

Dr Mohammad Bakhtiar

MD, PhD, LRCP, MSc, DHMSA

Sexual Health

GMC: 4694470•Last reviewed: January 2026

All medical content is reviewed by qualified healthcare professionals registered with the General Medical Council (GMC).

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Mycoplasma Genitalium: Key Facts

Often Asymptomatic

Incubation Period: 1–5 weeks
Test Window: 2 weeks post-exposure
Results: 3–5 working days
Treatment: Targeted antibiotics (resistance-guided therapy)
Cure Rate: 90–95% with resistance-guided treatment

Book Mycoplasma Test – £156

Results within 24 hours • Same-day treatment available